ReflectedImage's Karthus Guide

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Domination

Hunt and Eliminate Prey

Dark Harvest

Damaging a Champion below 50% health deals adaptive damage and harvests their soul, permanently increasing Dark Harvest's damage by 5.

Dark Harvest damage: 20-60 (based on level) (+5 damage per soul) (+0.25 bonus AD) (+0.15 AP)
Cooldown: 45s (resets to 1.5s on takedown)

Cheap Shot

Damaging champions with impaired movement or actions deals 10 - 45 bonus true damage (based on level).

Cooldown: 4s
Activates on damage occurring after the impairment.

Eyeball Collection

Collect eyeballs for champion takedowns. Gain an adaptive bonus of 1.2 Attack Damage or 2 Ability Power, per eyeball collected.

Upon completing your collection at 10 eyeballs, additionally gain an adaptive bonus of 6 Attack Damage, or 10 Ability Power.

Collect 1 eyeball per champion takedown.

Ultimate Hunter

Your ultimate gains 6 Ability Haste, plus an additional 5 Ability Haste per Bounty Hunter stack.

Bounty Hunter stacks are earned the first time you get a takedown on each enemy champion.

Precision

Become a Legend

Presence of Mind

Damaging an enemy champion increases your mana regeneration by 1.5 − 11 (based on level) (80% for ranged) mana per second for 4 seconds. All energy users gain 1.5 energy per second, instead.

Takedowns restore 15% of your maximum mana or energy.

Coup de Grace

Deal 8% more damage to champions who have less than 40% health.

Adaptive

5.4 bonus Attack Damage or 9 Ability Power

Adaptive

5.4 bonus Attack Damage or 9 Ability Power

Armor

6 bonus armor

Refillable Potion

ACTIVE
Consume
Restores 100 Health over 12 seconds.

Holds 2 charges and refills upon visiting the shop.

Total build cost: 500g

Hailblade

Sear: Damaging Monsters burns them over time.

Chilling Path: Smiting 5 times consumes this item upgrade your Smite to Chilling Smite and increases its damage to monsters. When smiting champions Chilling Smite deals true damage and steals their Move Speed.

Huntsman: Killing Large Monsters grants bonus experience.

Recoup: Regen mana when in the Jungle or River.

Consuming this item grants all item effects permanently and increases Smite damage to monsters. If you have gained more gold from minions than jungle monsters, gold and experience from minions is heavily reduced. Healing is not reduced on AoE attacks. If two levels behind the average champion level of the game, monster kills grant bonus experience.

Total build cost: 500g